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Progressive dopamine neuron loss following supra-nigral lipopolysaccharide (LPS) infusion into rats exposed to LPS prenatally

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During homeostasis, diverse cytosolic and extracellular DNases eliminate self-DNA that appears outside the nucleus and in addition, the cytoplasmatic expression of dsDNA sensors was believed sufficient to avoid erroneous immune responses to self-DNA: dying cells will usually release their DNA into the extracellular space, and DNA being a heavily negatively charged molecule does not normally pass through membranes