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Our data suggest that O-GlcNAcylation of Ezh2 and/or other co-factor(s) contributes to define the repertoire of Ezh2 targets in liver cancer and provide important insights for epigenetic strategies as potential future anti-HCC therapies

Glutamate can be further converted to -ketoglutarate (-KG) through oxidative deamination by glutamate dehydrogenase (GLUD1) or transamination by glutamate-linked transaminase as an anaplerotic substrate in the TCA cycle for energy production (Figure 1)

Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding

Ozempic is the brand name for semaglutide, a drug that helps people with diabetes manage their blood sugar levels