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Dunning and Schwartz 1981

Adotvi O, Vernerey D, Jacoulet P, Meurisse A, Laheurte C, Almotlak H, Jacquin M, Kaulek V, Boullerot L et al (2023) Safety, immunogenicity, and 1-year efficacy of universal cancer peptide-based vaccine in patients with refractory advanced non-small-cell lung cancer: a phase Ib/phase IIa de-escalation study

The pathophysiology of PASC is described right from the initiation of the novel SARS-CoV-2 infection by primordial hijacking of host cellular metabolic machinery, subsequent progression of virus-induced human metabolic reprogramming/dysregulation (HMRD) in a susceptible host, subjecting the patient through a crucial tri-phasic symptomatic clinical onset of COVID-19 (lasting from 34 weeks), and ultimate transition of a survivor into PASC or long-COVID, a virus-free state, lingering with earlier and/or new onset disease manifestations resulting from pre-acquired HMRD (lasting for weeks to months)

Kinetic death analyzes were performed automatically every 1 or 2 h with the cell by cell processing and segmentation module (Sartorius # 9600-0031), where the number of dead cells (Sytox + ) was constantly divided by the total number of cells in each image