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[1] [2] Other medicines, including metformin (used for type 2 diabetes, which often accompanies obesity), magnesium-containing supplements, and some antibiotics, may also cause diarrhoea

This ferroptosisinflammationhypoxia loop ultimately converges on fibrosis progression: pro-inflammatory cytokines (e.g., from activated macrophages) and hypoxic signals synergistically activate the TGF-/SmadHDAC3 pathway, downregulating anti-fibrotic Klotho and upregulating pro-fibrotic factors (e.g., collagen I/III)