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Collectively, GGCT functions as a metabolic rheostat that orchestrates mitochondrial homeostasis through diverting Gln flux toward glutathione biosynthesis to fortify redox defense, while enhancing Glc-fueled TCA cycle anaplerosis to sustain cell proliferation

Overall, GA was absorbed through the gastrointestinal tract, primarily distributed in the kidneys, then metabolized in the liver, and excreted by the kidneys

One of its proposed mechanisms of action is the preservation of glutathione levels in cardiomyocytes, thereby protecting against oxidative stress [99,100]

[3] The glycine cleavage system differs from the other complexes, and has a different nomenclature