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LF has multiple functions in host defense through binding iron, binding to bacterial membranes, inhibition of tumor necrosis factor-alpha (TNF-) and interleukin-1 (IL-1), stimulating the activity, maturation of lymphocytes, and contributing to an anti-oxidizing mileau ( There are numerous other HMGPs that have been described but the extent and specificity of their immune function need to be elucidated

CpG islands can be also found in non-promoter regions, such as intragenic CpG islands (from 300 bp downstream of the TSS to 300 bp upstream of the transcription termination siteTTS), 3-end CpG islands (from 300 bp upstream of the TTS to 300 bp downstream of the TTS), and intergenic CpG islands (from 300 bp downstream of the TTS of one gene to 1,000 bp upstream of the TSS of the following gene) [42, 43]

Hepatology 31 , 36 (2000)

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