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Cognitive decline: Low B-12 is associated with increased risk for Alzheimers disease, brain shrinkage, and general cognitive impairment especially for older adults

Similarly, rats exposed orally to aspartame (500 mg/kg bw per day for 1 week) showed fibrosis in splenic capsules, lymphoid depletion, and necrosis in the white pulp, accompanied by elevated levels of pro-inflammatory splenic transcripts of TNF and IL-6 (Ibrahim et al., 2022)

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Thus, labeling caudal to the L3/L4 boundary in PEG-fused animals (i.e., within the rostrocaudal range seen in Unoperated Control animals) is likely sciatic in nature due to successful PEG-fusion of severed sciatic nerves