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Together, these findings position cigarette butts as critical nodes in the urban resistome, emphasizing the need for targeted management and One Healthoriented interventions. The World Health Organization describes the One Health framework as an integrated, unifying approach that aims to sustainably balance and optimize the health of people, animals, and ecosystems.

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From 1962 to 1984 federal and state officials from the Department of Environmental Resources, the Office of Surface Mining, and the Bureau of Mines in the U.S

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