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Researchers theorize that asthma may be due to either inappropriate mast cell activation or that the mast cells are hypersecretory.[ref][ref] One study sums up that mast cells release preformed mediators including chymase, tryptase, and histamine and de novo synthesized mediators such as PGD2, LTC4, and LTE4 in addition of cytokines mainly TGF1, TSLP, IL-33, IL-4, and IL-13 participate in the pathogenesis of asthma.[ref] Related article : Asthma: understanding the genetics and underlying causes Osteoarthritis: Mast cells as a causative factor Osteoarthritis, the most common form of arthritis, is caused by inflammation and degeneration of the joint tissue

Castro-Marrero J, Faro M, Aliste L, Sez-Francs N, Calvo N, Martnez-Martnez A, et al

[8] The bioavailability of an IV medication is by definition 100%, unlike oral administration where medication may not be fully absorbed, or may be metabolized prior to entering the bloodstream

This would be especially beneficial for those who have to have their thyroid removed