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Efficacy and Safety of Semaglutide for Weight Loss in Obesity Without Diabetes: A Systematic Review and Meta-Analysis

However, SD was shown to increase the expression of both sAPP and -site APP-cleaving enzyme 1 in the hippocampus and prefrontal cortex while decreasing the expression of sAPP (Zhao et al., 2019), which undoubtedly worsens AD progression (Figure 3B)

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Its structural stability remaining intact under various experimental conditions makes it a reliable reference compound for laboratories investigating tissue repair mechanisms, angiogenic signaling, nitric oxide pathway interactions, and gastrointestinal biology in preclinical settings