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The overall lower total organic content for the FA-conjugated material (30%) compared with the non-conjugated drug-loaded SBA-15 (50%) implies that conjugation reduced the amount of physically adsorbed (free) drug for example by replacing weakly adsorbed drug with covalently tethered folic-aciddrug species or by additional washing steps removing unbound drug

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BMC Bioinforma 7:123 Nakajima J, Oana S, Sakaguchi T, Nakashima M, Numabe H, Kawashima H, Matsumoto N, Miyake N (2018) Novel compound heterozygous DPH1 mutations in a patient with the unique clinical features of airway obstruction and external genital abnormalities

Chen Y, Yan W, Chen Y, Zhu J, Wang J, Jin H, et al