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Through Fenton-like reactions and ionic interactions, copper catalyzes the generation of ROS, including superoxide anions (O 2 ), hydroxyl radicals (OH), and hydrogen peroxide (H 2 O 2 ) (Warnes et al., 2012

However, non-motor symptoms, ranging from cognitive impairment, mood disorders, sleep disturbances, autonomic dysfunction, to anosmia, are increasingly recognized as integral to the disease and often precede motor onset by years

Gene expression in HL60 granulocytoids and human polymorphonuclear leukocytes exposed in Candida albicans

Roozendaal B, Hernandez A, Cabrera SM, Hagewoud R, Malvaez M, Stefanko DP, Wood MA (2010) Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification