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Considering the important role played by the intestinal epithelium, which establishes a tightly regulated barrier, its integrity defects are frequently reported during intestinal inflammation (309)

Role of sirtuins in chronic obstructive pulmonary disease

Clock Gene Modulation Gene expression analysis following epitalon administration revealed alterations in: Clock gene (master circadian regulator) Cry2 gene (cryptochrome circadian component) Csnk1e gene (casein kinase involved in clock protein regulation) These gene expression changes occurred in peripheral leukocytes and lymphocytes, indicating systemic circadian regulation beyond central clock mechanisms [2]

Neuroimage (2006) 32:116775.10.1016/j.neuroimage.2006.04.227 115 BissiereSPlachtaNHoyerDMcallisterKHOlpeHRGraceAAet alThe rostral anterior cingulate cortex modulates the efficiency of amygdala-dependent fear learning