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10.3390/toxins13030190 18

However, through additional simulations, we observe that fluxes through reactions catalysed by all the three enzymes identified as transcriptionally regulated, including glucose-6-phosphate isomerase (PGI), acetaldehyde dehydrogenase (ACALD) and ribulose 5-phosphate 3-epimerase (RPE), were negatively correlated to mannitol production ( Fig