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The alterations described above impaired T-lymphocyte-mediated immune response, leading to a defect in the production of immune components such as IL-17, IL-22 (essential for mucosal antifungal defense) and IFN- (essential for tumor surveillance)

Discussion Clinical findings revealed severe intraocular inflammation and significant weight loss in Lewis rats immunized with IRBP emulsified in complete Freund adjuvant

Quercetin is a flavonoid molecule found in a variety of foods especially in apples and has antioxidant and anti-inflammatory properties [92, 93]

However, clinical trials are warranted to translate the promising preclinical findings into viable therapeutic approaches for TBI patients