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Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

doi: 10.3892/mmr.2020.11114 227 WangXLiuKGongHLiDChuWZhaoDet al

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There were also many studies in rats, and a few in mice, that showed the increased presence of ROS or activation of biomarkers of cellular responses to ROS, such as increased expression or activity of catalase, superoxide dismutase, or glutathione transferases in several tissues, including the liver, blood, spleen, kidney, and brain