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In humans, the number of synapses per SNc dopaminergic neuron increases tenfold, reaching between 1 and 2.4 million synapses (Bolam & Pissadaki, 2012

A deficiency of vitamin B6 can suppress transsulfuration, and lead to increased free radical production and oxidative stress.7,9 2

and in terms of vascular barrier function, the loss of HS exposes adhesion molecules, promoting the adhesion of leukocytes and platelets, triggering inflammation and thrombosis, and further impairing renal blood supply and glomerular filtration, ultimately leading to a decrease in GFR (100)

ROS are generated via electron transport reactions both in mitochondria and chloroplasts (Wise and Naylor, 1987