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Mullen W, Marks S, Crozier A

Furthermore, immunofluorescence double staining revealed that most ACSL4-positive cells were also positive for HNF-4, indicating that ferroptosis mainly occurred in hepatocytes at this stage of the experimental MASH mouse model

Although some of these correlations persist across disease or medication status, others appear to be lost among FENNS suggesting that steady formation of the antioxidant uric acid (UA) via purine catabolism is altered early in the course of illness