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Description

An in vitro study demonstrated that Leishmania sphingolipid-1 (LSPL-1) has cytotoxic effects and induces apoptosis in murine and human melanoma cells (B16F10 and A375 cell lines) by regulating the mitochondrial death pathway and generating reactive oxygen species

Petroni, M

Another study reported that RSL3 promotes the protein expression and acetylation of ALOX12, the key protein in initiating membrane phospholipid oxidation (Wang Y