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Based on the above limitations and perspectives, it is beneficial to address the question of how metabolic abnormalities develop in AAD in the future, thus determining which pathways are ideal therapeutic targets

To date, there is a wide range of affinity tags to choose from, but can adding a non-native peptide or fusion protein tag have adverse effects

Replenishing glutathione from dietary supplementation of Whey, N-Acetyl Cysteine, and Glutathione, are time- and dosedependant, but may further be inhibited by the influence of age, exercise stress, or environmental toxins

These postmortem results, along with those from the current and our previous study that highlighted a considerable number of differentially serum expressed amino acids between cases and controlsespecially in malessupport the idea that PD is a heterogeneous systemic disease that disrupts metabolic homeostasis across both central and peripheral organs (Costa et al., 2023)