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Inhibition of De Novo Pyrimidine Synthesis Depletes Acute Myleogenous Leukemia Stem Cells (LSCs) Burden and Triggers Apoptosis and Differentiation Associated with Oxidative Stress

Since ammonium is the only nitrogen source in MM medium, the gdh3 / gdh3 mutant may rely on Gdh2 to incorporate ammonium into glutamate

They are required to ensure normal metabolism and physical well-being, and they influence sleep quality and circadian factors

We analyzed the process of ferroptosis, explored the underlying pathological mechanisms of depression, and investigated potential connections between the ferroptosis signaling pathway and depression