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5 , e003407 (2016)

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Human microglia express roughly 50% fewer nanoparticle-targeting receptors, such as triggering receptors expressed on Myeloid cells 2 (TREM2), than rodent models, reducing cellular uptake [221]

This transformation was evidenced by the upregulation of the browning genes Ucp1 and Prdm16 , activation of HSL (p-HSL 660 ), and increased glycerol and free fatty acid release