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Nature 530 , 237241 (2016)

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Figure 5 7.1 Liposomes Liposomes loaded with cytokines, different RNAs, and carrying other therapeutic drugs have been proven to exert anti-tumor effects by inducing the proliferation of ACT T cells, increasing CD8 + T cells infiltration or their activity, or reducing the number of Tregs, such as pegylated liposomes using an F(ab)2 fragment of a unique cell surface antigen (Thy1.1) on ACT cells or an engineered IL-2 molecule on an Fc framework as targeting ligands to treat tumor bearing mouse can not only target ACT cells but also induce ACT T cells proliferation and stimulate ACT T cells to improve the efficacy of ACT (143)