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Thus, consensus screening frequencies have not been established, though some recommend initial baseline testing and at subsequent intervals of no more than 12 years

Additional limitations include the relatively small sample size (18 patients with 8 clinical pregnancies), the lack of randomization and control arms, and the absence of complete follow-up on pregnancy and delivery outcomes, which restrict the ability to fully evaluate the long-term impact of PRP therapy

That is useful for some applications but dangerous for others, particularly in people with cancer risk factors or metabolic disorders