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Per BNF and BSH guidance: For confirmed deficiency without neurological involvement: 1 mg IM on alternate days for two weeks, then 1 mg every two to three months for maintenance

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doi: 10.3389/fnut.2023.1068343 Received 12 October 2022 Accepted 21 March 2023 Published 05 April 2023 Volume 10 - 2023 Edited by Andrew Scholey, Monash University, Australia Reviewed by Jessica Zuiga-Hernandez, University of Talca, Chile

While the immune response that triggers inflammatory signaling cascades is unresolved, its progression could cause functional damage to neurons and glial cells, including astrocytes, microglia, and oligodendrocytes