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Microorganisms with claimed probiotic properties: an overview of recent literature

MASLD serves as an umbrella term that encompasses a broad spectrum of pathological liver changes from simple hepatic steatosis to steatohepatitis associated with metabolic dysfunction, which can lead to fibrosis and eventually progress to cirrhosis or hepatocellular carcinoma (HCC), while simultaneously increasing the risk of cardiovascular diseases (CVDs) and extrahepatic malignancies [1]

Reduced HNF4 binding to the Nr1i3 promoter and diminished Ppara expression has been observed in the liver during sepsis, which both contributed to the downregulation of Nr1i3 mRNA, as found in this study

In: Rosenthal GA, Janzen DH, editors