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We will review several hormones and their actions later in this chapter

Normally, Nrf2 is located in the cytoplasm and kept dormant by a cytoplasmic repressor Kelch-like ECH-associated protein 1 (Keap1)

A defining molecular hallmark is global DNA hypomethylation in lymphocytes, especially CD4+ T cells, which associates with disease activity and stabilizes a type-I-interferon-driven program