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178,179,180 In 2004, the FDA approved the first aptamer drug, pegaptanib (Macugen), to treat choroidal neovascularization caused by neovascular age-related macular degeneration (AMD)

doi: 10.1016/j.neuron.2019.12.007 118 UllandTKSongWMHuangSCUlrichJDSergushichevABeattyWLet al

10.1016/j.phymed.2018.09.199 111 JiangZ.ZhouY

Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IB kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3- thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation