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Worsening of Tourettes syndrome has also been reported

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To determine whether the haem-degrading activity of HMOX2 is essential for maintaining mitochondrial iron levels, we generated stable expression cells in which HMOX2 WT or HMOX2 HW/GW mutants were re-expressed in HMOX2 KO cells, and confirmed their subcellular localization to the ER (Extended Data Fig