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Pharmacokinetics (Ishida et al., 2020) Pooled PK data showed a half-life of about 11-12 minutes after either IV or subQ dosing, plasma clearance of 2.4-2.8 L/min, and rapid time-to-peak after subcutaneous injection

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Spatiotemporal loss of NF1 in Schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the hippo pathway