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Intlim: integration using linear models of metabolomics and gene expression data

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Protein misfolding and failure of clearance systems, including the autophagy-lysosome and ubiquitin-proteasome pathways, further compromise the cellular environment and lead to toxic intracellular accumulations [31, 32]

ATRX deficiency has been shown to accelerate GBM growth and reduce survival, linking ATRX loss to DNA repair deficiencies, particularly impaired nonhomologous end joining