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Our study conceptualizes a dual mode of action by which metronidazole and 5-nitroimidazole ethers induce stress and simultaneously inhibit the stress response with deleterious effects on bacterial survival

454 This abnormal generation of 2HG results in mTOR activation through the inhibition of KDM4A, an -KG-dependent lysine demethylase that stabilizes the mTOR suppressor DEPTOR