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Diffraction data were collected at the Pohang Accelerator Laboratory (PAL, beamline BL-7A) and were processed and scaled using the HKL-2000 package 31 (Table S2)

For glutamine starvation assays, cells were seeded in the same manner as described above in normal media

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OS plays an important role in chronic, inflammatory pathologies (Kehrer and Klotz, 2015), progressive brain damage and the pathogenesis of neurodegenerative diseases such as: Amyotrophic lateral sclerosis (ALS), Alzheimers disease (AD), Parkinsons disease (PD), Multiple sclerosis (MS), Huntingtons disease (HD), and Spinocerebellar ataxia (SA) (Dias et al., 2013