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The most recent comprehensive synthesis is a July 2025 systematic review in the HSS Journal , the musculoskeletal journal of the Hospital for Special Surgery in New York, led by Nikhil Vasireddi at Case Western Reserve University School of Medicine

There may be a benefit for high niacin for cholesterol where statins fail, in the acute post-stroke recovery phase, or for the treatment of recalcitrant cystoid macular edema, but the macula, blood sugar level, and liver enzymes must be monitored carefully