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160 Mechanistically, Cu can increase the production of ROS, which are intrinsically linked to malignant cell transformation

Interestingly, these authors found that butyrate enhances mitochondrial function as evidenced by increased ATP production in the cell lines that exhibits mitochondrial dysfunction but not in the cell lines that demonstrates normal functioning of the mitochondria

In hypoxic disc environments, hypoxia-inducible factor 1 alpha (HIF-1) activates autophagy pathways, helping to mitigate ROS generation while promoting chondrogenic differentiation and cartilage matrix synthesis [84]

8a) was obtained from the Protein Data bank, the structure of the SbDLDH proteins (Fig