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These dietary approaches share the principles of the traditional KD but differ in total energy supply, macronutrient distribution, and degree of restrictiveness

(PubMed) Gerstenberger JP, Bauer SR, Van Blarigan EL, et al

Additionally, the compound has poor oral bioavailability and is rapidly metabolized, while the biologically active trans isomer is chemically unstable, and few studies have employed standardized or bioavailable formulations