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J Cell Physiol 218:612622

Persistently high levels of TNF- and IFN- overactivate the tryptophan precursor metabolizing enzyme indoleamine 2,3-dioxygenase (IDO)

Other host barriers should also be considered as potential targets for prevention including the oral cavity and lung mucosa as these have been identified as sites of pathogenic autoreactive immune responses that contribute to autoimmune disease

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