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These data revived interest in the extracellular LLF glutathione pool and suggested that GGT activity in LLF is a novel target to treat asthma ( Human pharmacotherapy with acivicin, however, is limited by neurotoxicity and cytotoxicity caused by an extended inhibitory activity against a number of other glutamine-dependent biosynthetic enzymes ( in vivo , physical stability in vitro and extended inhibitory activity against mammalian as well as bacterial GGT ( MATERIALS AND METHODS INHIBITORY ACTIVITY OF GGsTop IN VIVO A crystalline form of GGsTop was synthesized according to the previous report ( C and aliquoted for experiments

Nature Reviews Neuroscience

Lowered function of the thyroid gland, regardless of the cause, can result in profound physiologic effects throughout virtually all systems of the body because of the effects of lowered temperature on enzyme function

[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Haschemi A et al