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This absence of IGF-1 stimulation is critical for appetite neutrality because IGF-1 has known effects on hypothalamic neuropeptide expression, including alterations to neuropeptide Y (NPY) and agouti-related peptide (AgRP), both potent appetite stimulators

Detection indicators: bone density (lumbar spine, hip), bone turnover markers (OC, CTX), bone microstructure (number, thickness, and gaps of bone trabeculae), and skeletal mechanical strength

The scale may not move dramatically at first because AOD-9604 targets fat specifically, and improvements may show up in measurements and mirror changes before the scale reflects them

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