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However, the efficacy of DMARDs in OA management remains a subject of ongoing research

95% CI: 0.419, 0.093), as shown in Fig

doi: 10.1038/ncomms13464 107 HenkeP

Solengepras (also known as CVN424) is a G-protein coupled receptor 6 (GPR6) inverse agonist primarily targeting D2 receptor expressing medium spiny neurons in the striatum and inhibiting the indirect basal ganglia pathway [150, 151]