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Mitsumoto H, Santella RM, Liu X, Bogdanov M, Zipprich J, Wu HC et al

Environ Toxicol Pharmacol 121:104922

Increased BDI-II scores resulted from items related to mental and physical fatigue (tiredness/fatigue, loss of energy, items referring to cognitive symptoms such as concentration difficulties) apart from one patient, who had a higher score across most items, while still not meeting the criteria for depression

The ANLS hypothesis proposes a coherent model where glutamate uptake by astrocytes stimulates their glycolysis, leading to lactate production and export, which is then taken up and oxidatively metabolized by neurons to meet activity-dependent energy demands (Brooks, 2018