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Free Cu never reaches the micromolar levels needed to inhibit either 5AR1 or 5AR2

This results in reduced nerve excitability

The animals were divided into six groups including the positive controls and negative controls along with the test group receiving caftaric acid with increasing doses up to 60 mg/kg on the 1 st , 4 th, and 7 th day, 1 hour prior to administration of cyclophosphamide