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Circulation 2014;130:554-564

CD4 + CD69 + T cells in the intestinal lamina propria of IBD patients produced significant amounts of pro-inflammatory cytokines, including IFN-, IL-13, IL-17A, and TNF-

2.5 Molecular dynamics The protein complexes formed with DSF and the standard drug underwent all-atom explicit molecular dynamics (MD) simulations for 100 ns in an explicit solvent using the ff99SBildn force field in xleap tool of Amber antechamber (Wang et al., 2001) with GROMACS software (Lindahl et al., 2001)