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A series of animal studies have confirmed the neuroprotective properties of FGF21 in conditions such as cerebral ischemia [22], hemorrhage [23], Parkinsons disease [24] and Alzheimers disease [25]

Acknowledgements We thank FigDraw (www.figdraw.com) for creating the model images and granting us copyright ownership

(vii) Given the emerging role of metabolic intermediates in signaling including succinate, itaconate, ketones inosine and arginine for example, begs the question whether other metabolites play regulatory roles in response to NAD + modulation

diseases like atherosclerosis and cancer may occur in part due to oxidative damage to tissues