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The complementary mechanisms work through multiple pathways: DSIP enhances delta wave sleep (the deepest restorative phase), regulates stress hormone rhythms including cortisol normalization, supports natural sleep-wake cycle optimization, and promotes recovery processes occurring during deep sleep stages

A second set of analyses examined people who already had a substance use disorder to see whether they later had substance-related emergency department visits, hospital admissions, deaths, overdoses, or suicidal ideation or attempts

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