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Trigonelline and diosgenin attenuate ER stress, oxidative stressmediated damage in pancreas and enhance adipose tissue PPARgamma activity in type 2 diabetic rats

*JAMA*, 281(15), 1415-1423

To determine whether these transcriptomic changes were reflected at the metabolic level, we quantified -hydroxybutyrate, a terminal product of -oxidation, in both cell lysates and culture supernatants