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Bounding the trait space We limit the possible trait combinations according to i) no tradeoff (open), ii) a convex bound, and iii) a concave bound (see Fig

They take advantage of altered vascular permeability and impaired lymphatic drainage but do not systematically use TME biology to guide design

Vigliante, I., Mannino, G., Maffei, M

In fact, unstimulated neutrophils and lymphocytes isolated from older adults patients accumulate greater amounts of ROS, present decreased SOD activity, and are less resistant to cell death compared to those cells obtained from young individuals (161)