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Prior to the fortification era, a case-control study showed that both red blood cell and serum folate concentrations were significantly lower in pregnant women with the T/T and C/T variants compared to the wild-type C/C genotype (24), suggesting inadequate folate metabolism with specific maternal genotypes

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Research has also investigated DRP-104 for its broader implications in tumor biology, including potential effects on oxidative stress balance, growth signaling pathways such as mTOR, and tumor microenvironment nutrient competition