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While healthy kidneys can flush out excess B12 since its water-soluble, those with impaired kidney function might struggle to eliminate it, leading to unwanted buildup in the blood

However, some studies also raise concerns due to its sedating properties and documentation of extra-medical use of this medication (Modesto-Lowe et al., 2019

In fact in IBD has been reported an upregulation of the pore-forming claudin-2 and down-regulation of occludin, particularly claudin-5 and -8 in Crohn's disease and claudin-4 and -7 in UC (83, 86, 326)

, commonly called black seed, belongs to the Ranunculaceae family and is grown and distributed in many parts of the world, particularly in Asian, Middle Eastern, Far Eastern, and East Mediterranean regions 15,16