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Hydrogen peroxide swiftly converts GSH to its oxidized form (GSSG) in this reaction

In contrast, the differentiation of neuronal SY5Y precursors or cardiomyocytes derived from human induced pluripotent stem cells was associated with an increased sensitivity to ferroptosis induced by GPX4 inhibition, correlating with an increase in PUFA plasmalogens

However, bilirubin is also neurotoxic at such high concentrations through mechanisms involving lipid peroxidation, as is for the case of hemin [233]

In the case of excessive ROS production, other redox-sensitive systems are affected, such as expression of endothelial nitric oxide synthase (eNOS) (4)